Merck
Senior Scientist - Vaccines and Advanced Biotechnologies Process R&D
West Point, PA
Feb 5, 2025
Full-time
Full Job Description

Job Description

Our department (Vaccines and Advanced Biotechnologies, VAX) Process R&D is responsible for the development and clinical manufacturing of DS and Drug Product Intermediates (DPI) for the vaccine and advanced therapy pipeline, spanning from preclinical to commercialization stages. We are part of the Process R&D organization, which enables modality-agnostic DS process development and clinical manufacturing for all of our company's pipeline. We interface closely with our Discovery organizations across Infectious Disease and Vaccines, Oncology, Neuroscience, and Immunology.

We are seeking an innovative, highly motivated, and experienced Senior Scientist to join us at our research site in West Point, PA (outside Philadelphia). The candidate will be responsible for conceiving, designing, and implementing experiments to advance the development of recombinant protein vaccines and therapeutics. This will require collaboration with cross-functional teams including colleagues in Discovery, Analytical, Formulation, and Enabling Technologies. The candidate should have a strong background in recombinant protein therapeutic/vaccine design and understanding of various purification modalities including but not limited to column chromatography (SEC, IEX, Affinity, MMC, HIC, Mixed/multi-mode, etc.) and tangential flow filtration (TFF, UF/DF), as well as advanced knowledge in protein handling and purification techniques. The candidate will be expected to independently design, execute, and analyze experiments.

The Sr. Scientist candidate must demonstrate well-developed skills for effective communication of scientific information in both written and verbal format and should have a strong history of publication in peer-reviewed journals. We value creative-thinking, teamwork, and independent analytical problem solving. If you are a highly motivated team player with a strong desire to impact basic research and translational medicine, we invite you to consider joining our team.

Position may require the employee to be willing to work with infectious agents and/or pathogens and/or potent compounds.Travel may be needed to support technology transfers. This position will require occasional off-hour and weekend work.

Responsibilities include but are not limited to:

  • Evaluation/optimization of purification strategies for recombinant protein vaccines

  • Collaborate on the evaluation/optimization of upstream and downstream process unit operations

  • Analysis of experiments through basic analytical techniques including SDS-PAGE, UV-Vis, HPLC, Western blot, etc.

  • Data interpretation and presentation, manuscript/patent preparation

Required or Preferred Experience and Skills:

  • Experience in purification unit operations using AKTA or similar FPLC systems

  • Knowledge of protein biochemistry (e.g., structure, function, modeling), and cutting-edge methodologies related to protein isolation/purification

  • Ability to understand and execute experiments independently in fulfillment of assigned program objectives in a manner that meets quality and timeline expectations

  • Well-developed organizational, record-keeping, and problem solving skills

  • Ability to work independently and/or in a team environment, and is results-oriented with examples from both ways of working

Education Minimum Requirement:

  • BS in Chemical Engineering or Biological Sciences or related discipline with at least 6 years of industrial experience or hands-on, laboratory work in the field of bioprocess and recombinant protein therapeutic/vaccine development.

  • MS in Chemical Engineering or Biological Sciences or related discipline with at least 3 years of industrial experience or hands-on, laboratory work in the field of bioprocess and recombinant protein therapeutic/vaccine development.

  • PhD in Chemical Engineering or Biological Sciences or related discipline (with expected graduation no later than May 2025).

#EBRG #vetjobs #PRD #eligibleforerp

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

1st - Day

Valid Driving License:

No

Hazardous Material(s):

N/A

Job Posting End Date:

02/19/2025

*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.


Requisition ID:R334046

PDN-9e22d6be-8563-4191-a4b2-d8b31eaee64b
Job Information
Job Category:
Science
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Senior Scientist - Vaccines and Advanced Biotechnologies Process R&D
Merck
West Point, PA
Feb 5, 2025
Full-time
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